Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
- 1 March 1990
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 114 (1-2), 109-120
- https://doi.org/10.1007/bf01311015
Abstract
Summary After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.Keywords
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