Molecular Models for Cholecystokinin-A Receptor
- 1 December 2002
- journal article
- review article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 91 (6), 290-296
- https://doi.org/10.1034/j.1600-0773.2002.910605.x
Abstract
Numerous techniques have been used to elucidate the structural basis for interaction of cholecystokinin (CCK)-related peptides with their hormone-binding receptor, the CCK-A receptor (CCK-AR), including structure-activity relationship studies, site-directed mutagenesis, photoaffinity-labeling, and solution NMR analysis of both CCK peptide ligands and peptide fragments derived from the CCK-A receptor. Different structural models have been developed for the peptide-receptor complexes using various subsets of the available experimental data (Giragossian & Mierke 2001; Ding et al. 2002; Escrieut et al. 2002). Here, we review details of the various models and evaluate the impact of selected experimental data sets on model development.Keywords
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