Peptide Uptake in Candida albicans

Abstract

Transport of radioactively labeled peptides was used to characterize a common transport system for di- and tripeptides in C. albicans. This permease is energy-dependent and has a requirement for L-amino acid residues, an .alpha.-linkage between residues and a free amino terminus. Transport was followed by the accumulation inside the cell of intact peptides and component amino acids. After transport of glycyl-[U-14C]phenylalanine the radioactive material was accumulated inside the cell and subsequently leaked into the medium under certain conditions.