Inverse Relation Between Low-Density Lipoprotein-Cholesterol and Dehydroisoandrosterone Sulfate in Human Fetal Plasma
- 2 May 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4443), 512-514
- https://doi.org/10.1126/science.6445079
Abstract
A striking inverse correlation was found in umbilical cord plasma between the concentrations of dehydroisoandrosterone sulfate and low-density lipoprotein (LDL)-cholesterol but not high-density lipoprotein-cholesterol or very low density lipoprotein-cholesterol. Dehydroisoandrosterone sulfate is a major secretory product of the human fetal adrenal and the principal precursor of placental estrogen production. The data suggest that the concentrations for LDL-cholesterol in fetal plasma are influenced by the rate of utilization of LDL-cholesterol by the fetal adrenal for steroidogenesis and are not necessarily related to a genetic predisposition for hypercholesterolemia or other lipoprotein disorders.Keywords
This publication has 18 references indexed in Scilit:
- Metabolic Studies in Familial HypercholesterolemiaJCI Insight, 1979
- SCREENING OF CORD BLOOD LOW‐DENSITY‐LIPOPROTEIN CHOLESTEROL IN THE DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLAEMIA: A STUDY OF 2000 INFANTSActa Paediatrica, 1979
- Low and High Density Lipoprotein Cholesterol Interrelationships in Neonates with Low Density Lipoprotein Cholesterol ≤ the 10th Percentile and in Neonates with High Density Lipoprotein Cholesterol ≥ the 90th PercentilePediatric Research, 1977
- CORD SERUM LIPID AND LIPOPROTEIN‐CHOLESTEROL VALUES IN NORMAL AND BETAMETHASONE‐TREATED NEWBORNS OF VARYING GESTATIONAL AGEActa Paediatrica, 1977
- Black-white similarities in cord blood lipids and lipoproteinsMetabolism, 1977
- PLASMA CONCENTRATIONS OF CORTISOL, PROGESTERONE AND UNCONJUGATED OESTRADIOL AND OESTRIOL IN WOMEN WITH LIVE ANENCEPHALIC FOETUSES BEFORE, DURING AND AFTER LABOURJournal of Endocrinology, 1976
- NEONATAL HYPERTRIGLYCERIDEMIA A New Index of Antepartum‐Intrapartum Fetal Stress?Acta Paediatrica, 1976
- Radioimmunoassay of Plasma Dehydroepiandrosterone SulfateAnalytical Letters, 1972
- Neutral C19-steroids amd steroid sulfates im human pregnancy I. Identification op dehydroepiandrosterone sulfate in fetal blood and quantification of this hormone in cord arterial, cord venous and maternal peripheral blood in normal pregnancies at termSteroids, 1964
- ADRENOCORTICAL STEROID METABOLISM AND ADRENAL CORTICAL FUNCTION IN LIVER DISEASEJCI Insight, 1960