Lioresal is a very effective compound in treatment of the neurogenic uninhibited bladder due to spinal cord lesions. It does not decrease, however, bladder spasms due to cerebral lesions. In detrusor-sphincter externus dyssynergia as frequently encountered in discreet spinal lesions Lioresal restores the normal reciprocal innervation of bladder and sphincter externus again. This effect is demonstrated electromyographically. Lioresal is of no effect on the normal bladder. Bladder capacity and micturition reflex before and after Lioresal therapy are unchanged.