Dissemination of Rat Cytomegalovirus through Infected Granulocytes and Monocytes In Vitro and In Vivo
- 15 October 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (20), 11274-8
- https://doi.org/10.1128/jvi.77.20.11274-11278.2003
Abstract
The role of leukocytes in the in vivo dissemination of cytomegalovirus was studied in this experiment. Rat cytomegalovirus (RCMV) could be transferred to rat granulocytes and monocytes by cocultivation with RCMV-infected fibroblasts in vitro. Intravenous injection of purified infected granulocytes or monocytes resulted in a systemic infection in rats, indicating that our model is a powerful tool to gain further insight into CMV dissemination and the development of new antivirals.Keywords
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