Pathogenesis of Influenza A (H5N1) Virus Infection in a Primate Model
- 15 July 2001
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (14), 6687-6691
- https://doi.org/10.1128/jvi.75.14.6687-6691.2001
Abstract
Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.Keywords
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