Norepinephrine Uptake, Smooth Muscle Sensitivity, and Metabolizing Enzyme Activity in Rabbit Veins
- 1 April 1974
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 34 (4), 541-548
- https://doi.org/10.1161/01.res.34.4.541
Abstract
Some parameters of the adrenergic neuroeffector mechanism were measured in vitro in the central ear (near the base of the ear), common jugular, pulmonary, brachial, femoral, renal, superficial cervical, cephalic, and small saphenous veins, a branch of the deep circumflex iliac vein, the parietal branch of the internal iliac vein, branches of the anterior mesenteric vein, the inferior vena cava (immediately distal to the left renal vein), and a subcutaneous vein of the back. Although extraneuronal uptake of 3H-norepinephrine was the same in all of the veins except the mesenteric, the neuronal uptake of norepinephrine varied widely. A number of veins, including the femoral and superficial cervical veins, showed no neuronal uptake, and the uptake of others, including the cephalic and mesenteric veins, was greater than that measured in any previously studied vascular tissue. The median effective dose for the contractile effect of norepinephrine on the veins was on the same order of magnitude as that for the aorta and the ear artery. Catechol-O-methyl transferase, but not monoamine oxidase, activity appeared to be related to innervation density. It is concluded that veins show a remarkable variation in the dimensions of their adrenergic parameters, particularly those related to innervation density.Keywords
This publication has 16 references indexed in Scilit:
- Evidence for Uneven Alpha-Receptor Distribution in the Rat Portal VeinCirculation Research, 1973
- The bimodal basis of the contractile response of the rabbit ear artery to norepinephrine and other agonistsEuropean Journal of Pharmacology, 1973
- Sympathetic Mechanisms in Blood Vessels: Nerve and Muscle RelationshipsAnnual Review of Pharmacology, 1973
- A direct method for recording tension changes in the wall of small blood vessels in vitroInflammation Research, 1972
- Distribution of components of 3H-noradrenaline uptake in the wall of the rabbit aortaEuropean Journal of Pharmacology, 1972
- Transmural and subcellular localization of monoamine oxidase and catechol-O-methyl transferase in rabbit aortaBiochemical Pharmacology, 1972
- NORADRENALINE METABOLIZING ENZYMES IN NORMAL AND SYMPATHETICALLY DENERVATED VAS DEFERENSJournal of Neurochemistry, 1971
- Adrenergic receptors in the veins of the dogEuropean Journal of Pharmacology, 1969
- A sensitive and specific assay for the estimation of monoamine oxidaseBiochemical Pharmacology, 1963
- DISTRIBUTION OF CATECHOL‐O‐METHYL TRANSFERASE IN THE NERVOUS SYSTEM AND OTHER TISSUESJournal of Neurochemistry, 1959