Effect of catalase inactivation on levels of inorganic peroxides, superoxide dismutase, glutathione, oxygen consumption and life span in adult houseflies (Musca domestica)

Abstract

The effects of total inhibition of catalase, induced by 3-amino-1,2,4-triazole, on the adult M. domestica were examined. The lack of catalase activity had no effect on the longevity of the houseflies. Inorganic-peroxide concentration was elevated at younger ages, but declined in older flies. The rate of O2 consumption by the flies was greatly decreased and the levels of oxidized as well as reduced glutathione were augmented. Superoxide dismutase activity showed a slight increase. Loss of catalase activity does not affect survival of houseflies due to adaptive responses.