Abstract
It is shown that the three-cocycle arises when a representation of a transformation group is nonassociative, so that the Jacobi identity fails. A physical setting is given: When the translation group in the presence of a magnetic monopole is represented by gauge-invariant operators, a (trivial) three-cocycle occurs. Insisting that finite translations be associative leads to Dirac's monopole quantization condition. Attention is called to the possible relevance of three-cocycles in the quark model's U(6) ⊗ U(6) algebra.