Reduction of multiplet complexity in COSY-type NMR spectra

Abstract
Procedures allowing for great simplification of the cross-peak multiplet structure in COSY-type two-dimensional NMR spectra are described on the basis of symmetry considerations. Bilinear mixing is discussed in detail and its features are elucidated experimentally. Maximum simplicity is obtained with planar mixing—a new method that is compared with isotropic mixing in total correlation spectroscopy.