THE EFFECT OF GROWTH HORMONE ON HEPATIC AND RENAL ACID AND ALKALINE PHOSPHATASES

Abstract

Hypophysectomy of immature, female rats resulted in an increase in the concn. of hepatic alkaline phosphatase and a decrease in the concn. of renal alkaline phosphatase, while the concns. of renal and hepatic acid phosphatases remained unchanged. Treatment of these rats with growth hormone partially restored values of hepatic alkaline phosphatase to normal, and completely restored those of renal alkaline phosphatase. The possible relationship of these changes to altered carbohydrate metabolism in the hypophysectomized rat is discussed. The acid phosphatases of both organs remained unchanged in hypophysectomized rats during treatment. Acid and alkaline phosphatases in liver and kidneys were unchanged in the intact rat by growth hormone treatment.