Der Abbau von aliphatischen Fettsäuren mit verzweigter Kohlenstoffkette durch überlebende Gewebsschnitte

Abstract

The formation of acetone or acetoacetic acid was used as a test for the successful catabolism of the acids. Liver slices formed acetone from the acids, but slices of kidney, spleen and lung were inactive. Methyl groups in the [alpha] position hindered decomposition considerably, but acids methylated and ethylated in the [beta] position, and those methylated in the [gamma], [delta], e and [zeta] position, were readily decomposed to acetone by liver, a process best explained by dealkylation. In the formation of acetone from [gamma]-methylvaleric acid and [gamma]-methylheptanoic acid, evidently both dealkylation and a or [gamma] oxidation take place.