The Metabolism of p32-Labeled Bayer L 13/59 in a Cow1

Abstract

The metabolism and excretion of p32-labeled Bayer L 13/59 (Dipterex) by a lactating Hereford cow and its uptake by encysted cattle grubs (Hypoderma bovis) were studied following oral administration of the compound to the host. The radioactive compounds present in the blood, milk, and urine were studied by paper chromatographic analysis and/or bioassay. Following its rapid metabolism the labeled degradation products are rapidly excreted via the urine, with about 66% of the dose accounted for at the end of 12 hours. Only low levels of radioactivity were detected in grubs removed at intervals after treatment.