Effect of Various Choline Esters upon the Secretion Rate of Adrenaline and Noradrenaline of the Adrenal Gland

Abstract

In dogs anesthetized with sodium pentobarbital, the adrenal venous blood was collected by the lumbar route method. Differential estimation of epinephrine and norepinephrine contents of the whole blood samples was made by a modification of the Weil-Malherbe and Bone method. After atropinization, an intravenous injection of acetylcholine, carbaminoylcholine, or benzoylcholine was made. By the injection of choline esters the adrenal epinephrine and norepinephrine secretion rates were increased markedly. The relative amount of norepinephrine to the total catecholamines liberated after injection of carbaminoylcholine was on the average 31% and that after acetylcholine and benzoylcholine was 14% and 11%, respectively.