Serologic Responses to Heterologous Escherichia Serogroups in Women with Pyelonephritis
- 26 December 1968
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 279 (26), 1407-1412
- https://doi.org/10.1056/nejm196812262792601
Abstract
Hemagglutinating antibody levels to 11 heterologous escherichia serogroups (01, 04, 06, 07, 014, 018, 025, 075, 077, 086 and 0119) measured in 61 women with pyelonephritis and 48 control women, showed significantly higher mean levels to 04, 06 and 086 in those with pyelonephritis. Individual levels to 04 and 06 often exceeded 1:100 in them. No escherichia organisms were recovered from the urine of a third of the persons with pyelonephritis, and yet in half of these elevated (1:100 or higher) levels to serogroup 04 or 06 were present. Elevated levels to 06 in particular, and to multiple escherichia serogroups in general, occurred primarily in younger women (under 50 years old) with pyelonephritis. Escherichia antibody patterns could not be attributed to nosocomial infection. It is concluded that elevated hemagglutinin levels to heterologous escherichia serogroups constitute an indicator of pyelonephritis that may be particularly useful in the study of asymptomatic conditions and in infections partially treated by antimicrobial therapy.Keywords
This publication has 23 references indexed in Scilit:
- Studies of Urinary Tract Infections in Infancy and ChildhoodActa Paediatrica, 1967
- Studies on the Epidemiology of Escherichia coli Infections. V. Factors Influencing Acquisition of Specific Serologic Groups*JCI Insight, 1967
- Studies of urinary tract infections in infancy and childhoodThe Journal of Pediatrics, 1965
- Significance of bacterial variants in urine of patients with chronic bacteriuria.JCI Insight, 1965
- Studies on the Epidemiology of Escherichia coli Infections. IV. Evidence for a Nosocomial Flora*JCI Insight, 1965
- SERUM-ANTIBODY LEVELS AS AN INDICATION OF CLINICALLY INAPPARENT PYELONEPHRITISThe Lancet, 1964
- Pathogenesis and laboratory diagnosis of non-tuberculous urinary tract infection: A reviewJournal of Clinical Pathology, 1964
- Studies of Urinary Tract Infections in Infancy and ChildhoodBMJ, 1963
- URINARY TRACT INFECTIONS IN GENERAL PRACTICEThe Lancet, 1962
- ACUTE URINARY INFECTIONS: THEIR COURSE AND OUTCOME IN GENERAL PRACTICE WITH SPECIAL REFERENCE TO CHRONIC PYELONEPHRITISThe Lancet, 1962