The Lung Strip: Evaluation of a Method to Study Contractility of Pulmonary Parenchyma
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Experimental Lung Research
- Vol. 2 (3), 187-195
- https://doi.org/10.3109/01902148109052314
Abstract
Isolated strips of rabbit lung were examined as an in vitro model for assessment of the direct effect of pharmacologic agents on the pulmonary parenchyma. Changes in force of the strip were measured with an isometric force transducer. Histamine, acetylcholine and epinephrine elicited dose-related contractile responses. Morphological and immunohistochemical examination revealed three possible sources of force generation within the strip: airway smooth muscle, vascular smooth muscle, and interstitial actin-containing cells. Generation of force by the strip could reflect contraction of any combination of these three elements. Therefore, ascription of such contraction to peripheral airway smooth muscle alone is questionable. In order to assess the properties of the contractile elements within the strip, it is necessary to isolate and study them individually.This publication has 15 references indexed in Scilit:
- Evaluation of the lung parenchyma strip preparation to measure bronchoactivityJournal of Pharmacological Methods, 1979
- Bronchodilator activity of dimaprit in the guinea pig in vitro and in vivoEuropean Journal of Pharmacology, 1979
- Binding of deoxyribonuclease I to actin: a new way to visualize microfilament bundles in nonmuscle cells.Journal of Histochemistry & Cytochemistry, 1978
- Comparative responses of tracheal spirals and parenchymal strips to histamine and carbachol in vitro.JCI Insight, 1978
- THE EFFECT OF CATECHOLAMINES ON THE in vivo AND in vitro RESPONSES OF THE CAT LUNG DURING ANAPHYLAXISBritish Journal of Pharmacology, 1977
- THE CAT LUNG STRIP AS AN in vitro PREPARATION OF PERIPHERAL AIRWAYS: A COMPARISON OF β‐ADRENOCEPTOR AGONISTS, AUTACOIDS AND ANAPHYLACTIC CHALLENGE ON THE LUNG STRIP AND TRACHEABritish Journal of Pharmacology, 1976
- Hypoxia on the pulmonary circulation. How and where it acts.Circulation Research, 1976
- Mechanisms underlying vasomotor regulation of regional pulmonary blood flow in normal and disease statesAmerican Journal Of Medicine, 1974
- "CONTRACTILE INTERSTITIAL CELLS" IN PULMONARY ALVEOLAR SEPTA: A POSSIBLE REGULATOR OF VENTILATION/PERFUSION RATIO?The Journal of cell biology, 1974
- GRANULATION TISSUE AS A CONTRACTILE ORGANThe Journal of Experimental Medicine, 1972