Composite Organic−Inorganic Nanoparticles as Raman Labels for Tissue Analysis
- 17 January 2007
- journal article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 7 (2), 351-356
- https://doi.org/10.1021/nl062453t
Abstract
Composite organic-inorganic nanoparticles (COINs) are novel optical labels for detection of biomolecules. We have previously developed methods to encapsulate COINs and to functionalize them with antibodies. Here we report the first steps toward application of COINs to the detection of proteins in human tissues. Two analytes, PSA and CK18, are detected simultaneously using two different COINs in a direct binding assay, and two different COINs are shown to simultaneously label PSA in tissue samples.Keywords
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