Plants as Sources of Antimalarial Drugs. Part 31Eurycoma longifolia

Abstract

Extracts of Eurycoma longifolia Jack (Simaroubaceae) have been tested for antiplasmodial activity against a multi-drug resistant Thailand strain (K-1) of Plasmodium falciparum in vitro. 10-Hydroxycanthin-6-one, eurycomalactone, eurycomanone and eurycomanol were isolated form the plant. The in vitro antimalarial activities of these compounds are reported together with that of 6-hydroxy-5, 6-dehydroeurycomalactone.