THE EFFECT OF BZ-55 (CARBUTAMIDE) ON THE GLUCOSE-6-PHOSPHATASE ACTIVITY IN THE LIVERS OF INTACT AND ALLOXANIZED FEMALE RATS

Abstract

The ingestion of the sulphonylurea BZ-55 (0.5 g./kg. body weight) by normal female rats for 8 days leads to a significant depression in the level of glucose-6-phosphatase activity in the liver of these animals. The glucose-6-phosphatase activity of the liver in alloxanized rats is higher than that of paired-fed control animals. The ingestion of BZ-55 by alloxanized rats causes this activity to be further increased as shown by comparison with the glucose-6-phosphatase activity in alloxanized, individually paired-fed controls. The differences in the effects of BZ-55 in normal and alloxanized animals are discussed.