Dyskinesia and wearing‐off following dopamine D1 agonist treatment in drug‐naive 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐lesioned primates
- 1 January 1996
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 11 (1), 91-94
- https://doi.org/10.1002/mds.870110117
Abstract
The motor effects of the short‐acting, full D1 agonist SKF 82958 were studied in three drug‐naive, 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine‐lesioned, parkinsonian monkeys treated for 4 weeks. D1 receptor stimulation with SKF 82958 effectively relieved parkinsonism but induced choreic dyskinesia (n = 2) and a shorter duration of motor benefit (n = 3) over time. Isolated, short‐lived D1 receptor activation would not appear to confer advantage over levodopa for dyskinesia prevention. Our data also support the involvement of postsynaptic dopamine receptor mechanisms in the wearing‐off phenomenon seen in levodopa‐treated parkinsonian patients.Keywords
This publication has 16 references indexed in Scilit:
- Levodopa or D2 agonist induced dyskinesia in MPTP monkeys: correlation with changes in dopamine and GABAA, receptors in the striatopallidal complexBrain Research, 1995
- Chronic CY 208–243 treatment of MPTP-monkeys causes regional changes of dopamine and GABAA receptorsNeuroscience Letters, 1993
- Differential efficacies of dopamine D1 receptor agonists for stimulating adenylyl cyclase in squirrel monkey and ratEuropean Journal of Pharmacology: Molecular Pharmacology, 1993
- Differential effect of chronic dopaminergic treatment on dopamine D1 and D2 receptors in the monkey brain in MPTP-induced parkinsonismBrain Research, 1993
- Synergistic and persistent interaction between the D2 agonist, bromocriptine, and the D1 selective agonist, CY 208–243Brain Research, 1992
- Effects of a selective partil D1 agonist, CY 208‐243, in de novo patients with Parkinson diseaseMovement Disorders, 1992
- Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacyEuropean Journal of Pharmacology: Molecular Pharmacology, 1990
- Differential effects of D 1 and D 2 agonists in MPTP‐treated primatesNeurology, 1990
- Levodopa-induced dyskinesias in parkinsonian monkeys: Relationship to extent of nigrostriatal damagePharmacology Biochemistry and Behavior, 1989
- Chronic treatment withl-DOPA, but not bromocriptine induces dyskinesia in MPTP-parkinsonian monkeys. Correlation with [3H]spiperone bindingBrain Research, 1986