Indices of granulocyte activity in inflammatory bowel disease
Open Access
- 1 December 1974
- Vol. 15 (12), 953-959
- https://doi.org/10.1136/gut.15.12.953
Abstract
In conditions with increased neutrophil production, the serum total vitamin B12-binding capacity (TBBC) is considered to correlate with the blood pool size of neutrophil granulocytes. The serum lysozyme, on the other hand, is a measure of neutrophil (and monocyte) turnover. The mean serum TBBC was significantly raised in patients with ulcerative colitis (range 1.23-5.51 ng/ml; mean 2.64 ng/ml) and patients with Crohn's disease (range 1.58-9.29 ng/ml; mean 2.93 ng/ml). The elevated values were shown to be due to rises in the granulocyte-secreted binding proteins, transcobalamins I and III. The TBBC was shown to rise with increasing activity of disease and to correlate roughly with the blood neutrophil granulocyte count. Patients with inflammatory bowel disease also had a significantly raised mean level of serum lysozyme (range 3.1 to 10.4 μg/ml; mean 6.8 μg/ml), but there was no correlation in individual patients between serum lysozyme and total B12-binding capacity. These results are taken to indicate an enlarged granulocyte pool and increased granulocyte turnover in inflammatory bowel disease.Keywords
This publication has 25 references indexed in Scilit:
- Levels in normal, Pathological, and foetal sera of the three transcobalaminsIrish Journal of Medical Science, 1973
- Assessment of the Value of Lysozyme Assay in NeutropeniaBritish Journal of Haematology, 1973
- Vitamin B12-Binding Protein Abnormality in Subjects without Myeloproliferative Disease: I. ELEVATED SERUM VITAMIN B12-BINDING CAPACITY LEVELS IN PATIENTS WITH LEUCOCYTOSISBritish Journal of Haematology, 1972
- Vitamin B12-Binding Protein Abnormality in Subjects without Myeloproliferative Disease: II. THE PRESENCE OF A THIRD VITAMIN B12-BINDING PROTEIN IN SERUMBritish Journal of Haematology, 1972
- Identification of a New Vitamin B12Binder (Transcobalamin III) in Normal Human SerumBritish Journal of Haematology, 1972
- The Presence of Inflammatory Leucocytes in the Rectal Mucus of Patients with Regional IleitisScandinavian Journal of Gastroenterology, 1971
- Serum Lysozyme and Vitamin B12Binding Capacity in Myeloproliferative DisordersBritish Journal of Haematology, 1971
- Release of vitamin B12—binding protein by human leukocytes in vitroJCI Insight, 1970
- Investigations into the Euglena method for the assay of the vitamin B12 in serumJournal of Clinical Pathology, 1964
- The Cytology of Colonic Secretion in Proctosigmoidal DiseaseActa Medica Scandinavica, 1962