Studies on YM-12617: A selective and potent antagonist of postsynaptic ?1-adrenoceptors

Abstract

YM-12617, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]-amino]propyl]-2-methoxybenzenesulfonamide HCl is a structurally new type of extremely potent α₁-adrenoceptor antagonist. Its α-adrenoceptor blocking properties have been compared with those of prazosin, phentolamine and yohimbine using both pharmacological and ³H-ligand binding techniques in vitro and in vivo.