Pc-G/trx-G and the SWI/SNF connection: Developmental gene regulation through chromatin remodeling
- 7 March 2000
- Vol. 26 (3), 189-197
- https://doi.org/10.1002/(sici)1526-968x(200003)26:3<189::aid-gene4>3.0.co;2-5
Abstract
Summary: Pc‐G and trx‐G genes are responsible for maintenance of transcriptional regulation and provide a cellular memory mechanism throughout development. Studies in fly, yeast, mouse, and human have implicated modulation of higher‐order chromatin structure as an important component in this process. Specifically, connections between SWI/SNF complexes and trx‐G genes have provided a mechanistic link between chromatin remodeling and transcriptional regulation. Here we discuss recent genetic and biochemical data that has shed light on the molecular mechanisms and pathways associated with Pc‐G and trx‐G function in developmental processes such as cell cycle control and hematopoiesis. genesis 26:189–197, 2000.This publication has 134 references indexed in Scilit:
- The “Dark Side” of Chromatin RemodelingCell, 1999
- Transcriptional control: SWItched-on mobilityCurrent Biology, 1999
- Stabilization of Chromatin Structure by PRC1, a Polycomb ComplexCell, 1999
- An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion OncogenesCell, 1996
- Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLFNature, 1995
- Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complexNature, 1994
- Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemiasCell, 1992
- The retinoblastoma protein and the regulation of cell cyclingTrends in Biochemical Sciences, 1992
- In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogasterNature, 1989
- Five SWI genes are required for expression of the HO gene in yeastJournal of Molecular Biology, 1984