Structure and evolution of mammalian ribosomal proteins
- 1 December 1995
- journal article
- review article
- Published by Canadian Science Publishing in Biochemistry and Cell Biology
- Vol. 73 (11-12), 933-947
- https://doi.org/10.1139/o95-101
Abstract
Mammalian (rat) ribosomes have 80 proteins; the sequence of amino acids in 75 have been determined. What has been learned of the structure of the rat ribosomal proteins is reviewed with particular attention to their evolution and to amino acid sequence motifs. The latter include: clusters of basic or acidic residues; sequence repeats or shared sequences; zinc finger domains; bZIP elements; and nuclear localization signals. The occurrence and the possible significance of phosphorylated residues and of ubiquitin extensions is noted. The characteristics of the mRNAs that encode the proteins are summarized. The relationship of the rat ribosomal proteins to the proteins in ribosomes from humans, yeast, archaebacteria, and Escherichia coli is collated.Key words: ribosomes, ribosomal proteins, amino acid sequence, evolution.Keywords
This publication has 54 references indexed in Scilit:
- Bilateral hydrophobic zipper as a hypothetical structure which binds acidic ribosomal protein family together on ribosomes in yeast SaccharomycescerevisiaeBiochemical and Biophysical Research Communications, 1991
- Nuclear targeting sequences — a consensus?Trends in Biochemical Sciences, 1991
- Molecular cloning and nucleotide sequence of cDNA specific for rat ribosomal protein L5European Journal of Biochemistry, 1987
- The effect of serum, EGF, PGF2α and insulin on S6 phosphorylation and the initiation of protein and DNA synthesisCell, 1982
- Preferential Utilization of Phosphorylated 40‐S Ribosomal Subunits during Initiation Complex FormationEuropean Journal of Biochemistry, 1982
- Phosphorylation of 40‐S Ribosomal Subunits by cAMP‐Dependent, cGMP‐Dependent and Protease‐Activated Protein KinasesEuropean Journal of Biochemistry, 1982
- The role of ethanol extractable proteins from the 80S rat liver ribosomeBiochemical and Biophysical Research Communications, 1980
- The ribosomal protein L8 is a complex of L7/L12 and L10FEBS Letters, 1976
- Copies of proteins L7 and L12 and heterogeneity of the large subunit of Escherichia coli ribosomeJournal of Molecular Biology, 1975
- The stimulation of the phosphorylation of ribosomal protein S6 by cycloheximide and puromycinBiochemical and Biophysical Research Communications, 1974