The Precision of the Conjunctival Provocation Test
- 1 January 1984
- Vol. 39 (1), 37-41
- https://doi.org/10.1111/j.1398-9995.1984.tb01931.x
Abstract
Repeated conjunctival provocation tests (CPT) were done in 20 children with rhinoconjunctivitis due to birch pollen allergy. Compared with the 1st open challenge, 3 successive blinded CPT were reproducible within an allergen strength difference of one 10-potency in 92% of the tests. Based on the data, a power function was constructed, making it possible to determine the number of patients needed to discriminate CPT sensitivity of a given magnitude between 2 populations. During the study period specific serum-IgE increased in 3 of 19 patients, indicating that stimulation of IgE antibody production is not a common consequence of repeated tests. Thus, CPT is useful in clinical research. When indicated in clinical routine, CPT is a safe and easy test with good precision.Keywords
This publication has 3 references indexed in Scilit:
- Allergen-specific IgE and IgG antibodies in pollen-allergic children given immunotherapy for 2-6 yearsClinical and Experimental Allergy, 1978
- Eye tests with inhalant allergens: Their feasibility, indications, and clinical valueJournal of Allergy, 1959
- XI. A dry pollen ophthalmic test in pollen asthma and hay fever patients negative to cutaneous testsJournal of Allergy, 1931