COMPARATIVE PARENTERAL AND ORAL ASSAYS OF ADRENAL CORTICAL HORMONE SUBSTANCES
- 31 July 1940
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 130 (2), 298-303
- https://doi.org/10.1152/ajplegacy.1940.130.2.298
Abstract
Adrenal cortex extracts given by stomach tube adm. assayed the same as when given by parenteral adm. Corticosterone and dehydrocorticosterone are also as effective orally as parenterally. Desoxycorticosterone assayed 35 rat units per mg. parenterally by subcut. inj., but orally this substance assayed less than one rat unit per mg. Cortical hormone activity could not be demonstrated in the feces of rats which had received desoxycorticosterone acetate by mouth. This substance is destroyed in the gut.This publication has 3 references indexed in Scilit:
- FRACTIONATION STUDIES ON ADRENAL CORTEX EXTRACT WITH NOTES ON THE DISTRIBUTION OF BIOLOGICAL ACTIVITY AMONG THE CRYSTALLINE AND AMORPHOUS FRACTIONSEndocrinology, 1939
- ORAL THERAPY IN ADRENAL INSUFFICIENCYEndocrinology, 1938
- THE USE OF ADRENAL CORTEX PREPARATIONS IN THE TREATMENT OF ASTHENIAEndocrinology, 1938