Agonist effects of .beta.-phenethylamines on the noradrenergic cyclic adenosine 3',5'-monophosphate generating system in rat limbic forebrain. Stereoisomers of p-hydroxynorephedrine

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Abstract
Significant agonist activity for the specific noradrenergic c[cyclic]AMP generating system in rat limbic forebrain required a .beta.-3,4-dihydroxyphenethylamine with a .beta.-hydroxyl group in the R configuration. Neither of the enantiomers of p-hydroxynorephedrine, a metabolite of amphetamine, nor of p-hydroxynorpseudoephedrine mimicked the agonist activity of (R)-norepinephrine. Whether or not 1 of the p-hydroxynorephedrines exhibits antagonist activity in this same system was not established.