The discovery by McVay, Laird and Sprunt1that aureomycin is effective in the treatment of amebiasis offered a new mode of antibiotic attack against this widespread and tenacious disease. The purpose of this paper is not to discuss amebiasis in general, which has been reviewed adequately elsewhere,2but specifically to report on the treatment with aureomycin of 38 patients seen in private practice. No claim is made that the dosage of the drug employed in this series of patients was adequate. Indeed, it is obvious that even more vigorous use of aureomycin is indicated than is herein reported. METHOD OF SELECTION OF PATIENTS All patients selected for this study had active amebiasis with persistent symptoms and positive stools. Almost without exception all had had repeated ineffective courses of carbarsone and diiodo-hydroxyquinoline (diodoquin®) administered as follows: carbarsone (0.25 Gm.) after each meal for ten days followed by three tablets