RELATIVE ORAL ANABOLIC TO ANDROGENIC ACTIVITY RATIOS OF ANDROISOXAZOLE, ETHYLESTRENOL, METHYLANDROSTENOLISOXAZOLE AND TESTOSTERONE

Abstract

Androisoxazole, 17[alpha]-methylandrost-4-en-17[beta]-ol[2,3-d] isoxazole, 17[alpha]-ethyl-19-nor-estra-4-en-17[beta]-ol and testosterone were evaluated experimentally for anabolic activity by means of nitrogen balance studies and for androgenic activity on the basis of increase weight of the ventral prostate gland in a 10-day assay. Under these conditions their anabolic:androgenic activities relative to methyltestosterone (= 1.0) and ratios were: androisoxazole (1.55/0.22) 7.0, methylandrostenol-isoxazole (1.2/0.15) 8.0, ethylestrenol (1.7/0.21) 8.1 and, of historical interest, testosterone (0.38/0.57) 0.67. The first 3 agents thus are intermediate in degree of dissociation of anabolic and androgenic properties between methyltestosterone and the more promising isoxazole-conjugated and pyrazole-conjugated (stanozolol) agents discussed previously.