Role of Arterial Wall Secretion in the Regulation of Blood Pressure

Abstract

The authors present experiments demonstrating that the hypertension produced by the stimulation of the central end of the vagus nerve is brought about by the appearance of a pressor substance in the circulating blood. The results of these experiments show that such a substance does not come from any gland nor from the central nervous system. The observed facts indicate that its origin is the arterial wall proper, from which it is directly liberated into the circulation. The pharmacologic proofs suggest that this substance is noradrenaline.