TESTICULAR HISTO-MORPHOLOGY OF YOUNG RATS TREATED WITH OESTRADIOL-17β BENZOATE
- 1 May 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 46 (1), 25-30
- https://doi.org/10.1530/acta.0.0460025
Abstract
Oestradiol-17[beta] benzoate, 120 [mu]g, injected into 5-day old male rats inhibited maturation of the seminiferous epithelium as demonstrated by histologi-cal studies performed 40-55 days post-treatment. The oestrogen treatment was ineffective when administered at the age of 20 days. The degree of testicular damage appeared to be correlated with the amount of steroid used. A dose of 240 [mu]g of oestradiol benzoate led to severe pathological changes in almost 100% of the seminiferous tubules and atrophy of the Leydig cells.Keywords
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