Inv(1) Allotype: Effect of Immunoglobulin G Heavy Chain Subtype on Its Expression
- 30 May 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 164 (3883), 1072-1073
- https://doi.org/10.1126/science.164.3883.1072
Abstract
More protein is required to detect the Inv(1) antigen carried in the light chain of immunoglobulin G molecules when the light chain is combined with a γ2 heavy chain than when it is combined with a γ1 or γ3 heavy chain. One of the four γ2 heavy chains used in the experiment, however, was as efficient as the γ1 and γ3 chains, indicating that there may be two subtypes of γ2. Inv(1) was more easily detected in one of the two light chains used in the experiment. This difference may be associated with the subtypes of the kappa chain derived from studies of the variable portion of the chain.Keywords
This publication has 10 references indexed in Scilit:
- Linked Groups of Residues in Immunoglobulin κ ChainsNature, 1967
- Two Structurally Distinct Classes of Kappa-chains in Human ImmunoglobulinsNature, 1967
- The Relationship between the Inv (1) and (2) Genetic Antigens of Kappa Human Light ChainsThe Journal of Immunology, 1967
- The effect of the interaction of heavy and light chains of IgG on the Gm and Inv antigensBiochemical Genetics, 1967
- Two Types Of Lambda Polypeptide Chains In Human ImmunoglobulinsScience, 1967
- Studies on the Variability of Immunoglobulin SequenceCold Spring Harbor Symposia on Quantitative Biology, 1967
- GM AND INV FACTORS IN SUBCLASSES OF HUMAN IGGThe Journal of Experimental Medicine, 1965
- Dependence of a Gm(b) Antigen on the Quaternary Structure of Human Gamma GlobulinScience, 1964
- Population, Immunogenetic, and Biochemical Studies on the Gm(b) Factors of Human Gamma GlobulinCold Spring Harbor Symposia on Quantitative Biology, 1964
- Localization of Two Genetic Factors to Different Areas of γ-Globulin MoleculesScience, 1962