Lipoprotein lipase suppression in 3T3‐L1 cells by a haematoprotozoan‐induced mediator from peritoneal exudate cells
- 1 May 1984
- journal article
- research article
- Published by Wiley in Parasite Immunology
- Vol. 6 (3), 203-209
- https://doi.org/10.1111/j.1365-3024.1984.tb00793.x
Abstract
Summary Lysates of the haematoprotozoa Trypanosoma brucei or Plasmodium berghei stimulated murine peritoneal exudate cells to release a mediator, which suppressed lipoprotein lipase activity in differentiating 3T3-L1 preadipocytes. The parasite-induced mediator suppressed the activity of cell surface lipoprotein lipase up to 39% in a dose dependent manner. By impairing the activity of cell surface lipoprotein lipase, this mediator acts to inhibit the uptake of fatty acid, and ultimately the accumulation of lipid by the adipocyte. In vivo this defect in triglyceride removal may explain the hypertriglyceridemia commonly observed in haematoprotozoan infections. We suggest that the lipoprotein lipase suppression mediator is produced as a consequence of the immune response to these parasitic protozoa.Keywords
This publication has 13 references indexed in Scilit:
- Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells.Proceedings of the National Academy of Sciences, 1983
- Inhibition of the growth and differentiation of erythroid precursor cells by an endotoxin-induced mediator from peritoneal macrophages.Proceedings of the National Academy of Sciences, 1983
- Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells.Proceedings of the National Academy of Sciences, 1982
- Host Susceptibility to African Trypanosomiasis: TrypanotoleranceAdvances in Parasitology, 1982
- Studies of endotoxin-induced decrease in lipoprotein lipase activity.The Journal of Experimental Medicine, 1981
- Kinetic study of serum lipoproteins, total cholesterol and triacylglycerides in various models of experimental rodent malariaPathogens and Global Health, 1980
- Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: Role of defective triglyceride removalMolecular and Biochemical Parasitology, 1980
- A stable, radioactive substrate emulsion for assay of lipoprotein lipaseJournal of Lipid Research, 1976
- Isolation of salivarian trypanosomes from man and other mammals using DEAE-celluloseExperimental Parasitology, 1970
- Genetic Control of Leucocyte Responses to EndotoxinNature, 1968