Amphetamine in Human Plasma: A Sensitive and Specific Enzymatic Assay
- 1 February 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4123), 420-421
- https://doi.org/10.1126/science.183.4123.420
Abstract
Development of irreversible platelet aggregation and the accompanying release of platelet-bound serotonin and production of prostaglandins is suppressed by 5,8,11,14-eicosatetraynoic acid (TYA). These findings may be explained by an ability of TYA to inhibit the enzymatic conversion of arachidonate to a newly recognized factor, labile aggregation-stimulating substance, which induces platelet aggregation, and to prostaglandins E2 and F2α.Keywords
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