ALTERED REGULATION OF MITOGEN RESPONSIVENESS BY SUPPRESSOR CELLS IN MULTIPLE-SCLEROSIS
- 1 January 1979
- journal article
- research article
- Vol. 36 (1), 78-84
Abstract
Suppression of the lymphocyte response to concanavalin (Con) A, phytohemagglutinin (PHA) and protein A from Staphylococcus aureus (SpA) by Con A-induced suppressor cells was measured in 24 patients with recently active-recovering multiple sclerosis (MS), 12 with inactive MS and 23 healthy controls. Patients with recently active disease displayed significantly greater suppression of the response to Con A. Suppression of the responses to PHA and SpA did not differ among the groups. Lymphocyte stimulation in cultures not showing suppression was similar in all 3 types of subjects. Lymphocyte regulation is apparently disturbed in patients with recently active-recovering MS. The potential usefulness of measuring the suppression of responsiveness to several mitogens is shown.This publication has 26 references indexed in Scilit:
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