14C triolein breath test: a routine test in the gastroenterology clinic?
Open Access
- 1 November 1986
- Vol. 27 (11), 1347-1352
- https://doi.org/10.1136/gut.27.11.1347
Abstract
The absorption of 14C triolein in a standard fat meal was measured in 60 controls and 66 patients with gastrointestinal disorders by 14CO2 breath sampling. A reference range based upon cumulative eight hour values of the controls was independent of height, weight, and sex. The range was of log normal distribution and declined with age (p less than 0.05). Acceptable 'within-day' and 'between-day' reproducibility was found. All patients tested with untreated coeliac disease, pancreatic insufficiency and most with symptomatic small intestinal Crohn's disease had subnormal values. Twenty per cent of those with irritable bowel syndrome had subnormal values. Patients with ulcerative colitis were all normal. The reagents used and the breath samples after collection were stable. In our experience the 14C triolein test is simple, inexpensive, and helpful in the detection of diseases associated with fat malabsorption. It is of value in monitoring the response to treatment of individual patients with coeliac disease.This publication has 11 references indexed in Scilit:
- Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention.BMJ, 1985
- Faecal Fat and Faecal Weight: Reproducibility and Diagnostic Efficiency of Various RegimensScandinavian Journal of Gastroenterology, 1984
- Have Chemical Tests a Role in Diagnosing Malabsorption?Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1984
- CLINICAL EVALUATION OF THE “GTRIOLEIN BREATH TEST: A CRITICAL ANALYSISAustralian and New Zealand Journal of Medicine, 1984
- 14C-Triolein Breath Test as a Rapid and Convenient Screening Test for Fat MalabsorptionScandinavian Journal of Gastroenterology, 1983
- Comparison of simple screening tests for fat malabsorption.BMJ, 1981
- The glyceryl [14C]tripalmitate breath test: A reassessmentClinica Chimica Acta; International Journal of Clinical Chemistry, 1980
- TRIOLEIN BREATH TEST - SENSITIVE AND SPECIFIC TEST FOR FAT MALABSORPTION1979
- Idiopathic bile acid catharsis.Gut, 1976
- Measurement of intestinal fat absorption with carbon-14 labeled tracers.1968