On the basis of angiographic, microangiographic and histologic studies of normal and neoplastically altered adrenal glands suitable roentgenographic methods for examining suspected changes of the adrenal glands are discussed. The difficulties of differential diagnosis are pointed out. The most suitable examination technique from the anatomic aspect would seem to be bilateral adrenal phlebography, possibly combined with an injection of small doses of adrenalin via the renal arteries to reduce the blood flow.