Upconverting Nanoparticles as Nanotransducers for Photodynamic Therapy in Cancer Cells
- 30 January 2008
- journal article
- Published by Taylor & Francis in Nanomedicine
- Vol. 3 (1), 73-82
- https://doi.org/10.2217/17435889.3.1.73
Abstract
Photodynamic therapy (PDT) involves killing of diseased cells by excitation of photosensitizer chemicals with high-energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high-energy light and hydrophobic photosensitizers limits the effectiveness to superficial pathologies. Upconversion phosphor nanoparticles convert low-energy radiation to higher-energy emissions. To create upconverting 'nanotransducers' to enable PDT in deep tissues. Monodisperse, 50 nm PEI/NaYF(4):Yb(3+),Er(3+) nanoparticles producing green/red emission on near-infrared (NIR) excitation were targeted to folate receptors on human colon cancer cells and imaged with high signal-to-background ratio. It was demonstrated that these particles could be excited after deep intramuscular injection in rats. On NIR excitation, the particles, modified with zinc phthalocyanin photosensitizer, released singlet oxygen and, after targeted binding to cancer cells, resulted in significant cell destruction. Potential clinical use of these nanoparticles includes imaging and PDT of cancer in deep tissues.Keywords
This publication has 21 references indexed in Scilit:
- Nanoparticles for Two-Photon Photodynamic Therapy in Living CellsNano Letters, 2006
- Design of a Highly Sensitive and Specific Nucleotide Sensor Based on Photon Upconverting ParticlesJournal of the American Chemical Society, 2006
- Er, Yb Doped Yttrium Based Nanosized Phosphors: Particle Size, “Host Lattice” and Doping Ion Concentration Effects on Upconversion EfficiencyJournal of Fluorescence, 2006
- A phase‐1 study of sequential mitomycin C and 5–aminolaevulinic acid‐mediated photodynamic therapy in recurrent superficial bladder carcinomaBJU International, 2005
- Highly Efficient Multicolour Upconversion Emission in Transparent Colloids of Lanthanide‐Doped NaYF4 NanocrystalsAdvanced Materials, 2004
- The cost-effectiveness of Foscan mediated photodynamic therapy (Foscan-PDT) compared with extensive palliative surgery and palliative chemotherapy for patients with advanced head and neck cancer in the UKOral Oncology, 2004
- Photodynamic Therapy Using Topical Methyl Aminolevulinate vs Surgeryfor Nodular Basal Cell CarcinomaArchives of Dermatology, 2004
- Photodynamic therapy for lung cancer — A review of 19 years' experienceJournal of Photochemistry and Photobiology B: Biology, 1998
- Photodynamic therapy: An effective, but non-selective treatment for superficial cancers of the oral cavityInternational Journal of Cancer, 1997
- Photodynamic Therapy in Head and Neck CancerJAMA Otolaryngology–Head & Neck Surgery, 1985