SINGLE PEPTIDE DIFFERENCES BETWEEN γ-GLOBULINS OF DIFFERENT GENETIC (Gm) TYPES
- 1 June 1964
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 51 (6), 1007-1014
- https://doi.org/10.1073/pnas.51.6.1007
Abstract
Fingerprint analyses of the F fragments and A chains of 22 subjects at different Gm types have demonstrated the presence of a peptide spot in (a+) subjects which cannot be seen in (a-) proteins, and another spot in (b+) proteins which is lacking in (b-) subjects. Other minor variations were occasionally seen, but did not correlate with the Gm (a, b, or x) type. The findings suggest that these differences reside in a single amino acid substitution reflecting a change in a single base pair.Keywords
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