Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6
- 1 January 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 337 (6205), 370-373
- https://doi.org/10.1038/337370a0
Abstract
Although infection by HIV-1 has been implicated as the primary cause of AIDS and related disorders, cofactorial mechanisms may be involved in the pathogenesis of the disease. For example, several viruses commonly detected in AIDS patients and capable of transactivating the long terminal repeat of HIV-1, such as herpesviruses, papovaviruses, adenoviruses and HTLV-I have been suggested as potential cofactors. Another candidate is human herpesvirus-6 (HHV-6, originally designated human B-lymphotropic virus), which has not only been identified in most patients with AIDS by virus isolation, DNA amplification techniques and serological analysis, but is also predominantly tropic and cytopathic in vitro for CD4+ T lymphocytes. Here we demonstrate that HHV-6 and HIV-1 can productively co-infect individual human CD4+ T lymphocytes, resulting in accelerated HIV-1 expression and cellular death. We also present evidence that HHV-6 transactivates the HIV-1 long terminal repeat (LTR). These observations indicate that HHV-6 might contribute directly or indirectly to the depletion of CD4+ T cells in AIDS.Keywords
This publication has 23 references indexed in Scilit:
- Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T CellsScience, 1988
- HBLV (orHHV-6) in human cell linesNature, 1987
- A NOVEL LYMPHOTROPIC HERPESVIRUSThe Lancet, 1987
- ISOLATION OF HUMAN LYMPHOTROPIC HERPESVIRUSES FROM UGANDAThe Lancet, 1987
- Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative DisordersScience, 1986
- Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)Science, 1985
- Antibodies Reactive with Human T-Lymphotropic Retroviruses (HTLV-III) in the Serum of Patients with AIDSScience, 1984
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDSScience, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983