EFFECT OF ACID-BASE CHANGES ON EXPERIMENTAL CONVULSIVE SEIZURES

Abstract

Mild metabolic acidosis and severe respiratory acidosis have no effect upon the electroshock seizure threshold of rats. Severe metabolic acidosis raises the threshold about 14%, and mild and severe metabolic alkalosis lower the threshold about 7%. Severe respiratory acidosis has no effect upon the threshold convulsive dose of metrazol or picrotoxin. Severe metabolic acidosis or alkalosis has no effect upon the maximal seizure pattern of rats, or upon the resting electroencephalogram, the subconvulsive metrazol eeg discharge and the threshold for evoked cortical potentials in rabbits.