Plasma cobalamin-binding and serum cobalamin in patients with folate deficiency
- 24 April 2009
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 34 (2), 191-195
- https://doi.org/10.1111/j.1600-0609.1985.tb02255.x
Abstract
Plasma unsaturated R-binder and transcobalamin 2 (TC 2) levels were measured in 62 patients with folate deficiency and compared with 80 control subjects and 52 patients with pernicious anemia [PA]. An increase in unsaturated R-binder concentration was found in the majority of patients with folate deficiency and with PA. In folate deficiency the unsaturated R-binder was often elevated whether the serum cobalamin (Cbl) was low or normal, more frequently when the serum Cbl was normal. Results of a separate in vivo study of plasma retention of injected 57Co cyanocobalamin were consistent with these findings. An elevated TC 2 was found in a small number of patients with folate deficiency and with PA. The serum Cbl appears to be maintained at a normal level in some patients with folate deficiency by an increase in R-binder, which is caused by folate deficiency itself.Keywords
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