The Effect of Carcinoid Levels of Serotonin and Substance P on Hemodynamics
- 1 February 1984
- journal article
- research article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 199 (2), 197-204
- https://doi.org/10.1097/00000658-198402000-00012
Abstract
Serotonin and substance P circulate in high concentrations in patients with the carcinoid syndrome. These studies were performed to evaluate the effects of intravenous infusions of serotonin and substance P to reproduce carcinoid levels of these agents on central hemodynamics, regional blood flow (using the radioactive microsphere technique), and endogenous hormone release. Serotonin did not affect mean arterial pressure but it significantly increased cardiac output, decreased systemic vascular resistance, and redistributed regional blood flow, increasing blood flow to the heart, adrenals, fundus, and antrum. Substance P significantly decreased mean arterial pressure and systemic vascular resistance, increased cardiac output, and increased blood flow to adrenal, fundus, antrum, liver, and all muscular layers of the stomach and small bowel. Neither serotonin nor substance P affected skin blood flow, nor altered circulating levels of glucose, insulin, or gastrin. Although both of these agents seem to participate in the pathogenesis of the carcinoid syndrome, our studies suggest that it is not possible to ascribe all the hemo-dynamic abnormalities to either.This publication has 38 references indexed in Scilit:
- Local regulation of blood flow in the feline jejunum. A possible role for endoluminally released substance P.JCI Insight, 1982
- Substance P in an argentaffin carcinoid of the caecum: Biochemical and biological characterizationVirchows Archiv, 1981
- Substance P: A Powerful intestinal vasodilator in the pigPflügers Archiv - European Journal of Physiology, 1980
- Corticosteroidogenesis by isolated human adrenal cells: Effect of serotonin and serotonin antagonistsCellular and Molecular Life Sciences, 1979
- Validation and Application of a Radioimmunoassay for SerotoninGastroenterology, 1976
- Pharmacologic and Endocrine Aspects of Carcinoid SyndromePublished by Elsevier ,1967
- RELEASE OF A KININ PEPTIDE IN THE CARCINOID SYNDROMEThe Lancet, 1964
- Studies on carcinoid disease.1958
- A study of 356 carcinoids of the gastrointestinal tract: Report of four new cases of the carcinoid syndromeAmerican Journal Of Medicine, 1956
- PAROXYSMAL FLUSHING AND OTHER SYMPTOMS CAUSED BY 5-HYDROXYTRYPTAMINE AND HISTAMINE IN PATIENTS WITH MALIGNANT TUMOURSThe Lancet, 1954