THE proved value of the sulfonamides for systemic use has led to a widespread application of these drugs for the treatment of surface infections. Recent studies tend to show that the type of base used as a vehicle for sulfonamides is of great importance. In 1941, Pillsbury and his co-workers1 showed clinically that sulfathiazole is not so effective in an all-grease base as in an oil-in-water emulsion or stearate vanishing-cream base. In 1942, Gurd, Ackman, Gerrie and Pritchard2 likewise pointed out that an oil-in-water emulsion base for sulfonamides is more desirable. Diffusion studies by Waud and Ramsay3 showed that fatty . . .