Interaction of rat α‐fetoprotein and albumin with polyunsaturated and other fatty acids: Determination of apparent association constants
- 19 June 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 250 (1), 22-24
- https://doi.org/10.1016/0014-5793(89)80676-3
Abstract
The interaction of fatty acids with rat α-fetoprotein and albumin was measured using a partition equilibrium method. α-Fetoprotein (AFP) displays one high-affinity binding site for fatty acids and albumin near two binding sites. The AFP association constants for most fatty acids were similar to those of albumin (in the 107 M−1 range) whereas for docosa-hexaenoic acid it was 9.7 × 108 M−1, about 50-fold higher than that corresponding to albumin. This difference justifies docosahexaenoic acid in fetal or neonatal serum being mainly bound to AFP and can indicate a highly specific role of AFP in the transport of this fatty acid.Keywords
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