Anti-tumor Activity of Compound Derived from Diketene and Their Related Compounds

Abstract

Various derivatives containing acetoacetamide, .beta.-aminocrotonamide, pyrimidine, pyridine, dihydroxybenzoic acid, quinoline, pyridone, 2-pyrone and 2-pyrrolidone were prepared from diketene. Their antitumor activities were examined by use of ascitic or solid mouse Ehrlich carcinoma, and among them 11 compounds had some antitumor effects on this solid tumor. These compounds were derivatives of pyrimidine (no. 30), pyridine (no. 41, 42, 54, 55, 56, 57 and 63), 2-pyrone (no. 124 and 125) and pyridopyrimidine (no. 137). No correlation was found between antitumor activity and these derivatives. No other substances were effective.