NARCOTIC CUE - EVIDENCE FOR SPECIFICITY OF STIMULUS PROPERTIES OF NARCOTIC DRUGS

Abstract

Various non-narcotic drugs [chlordiazepoxide, spiperone, pentobarbital sodium, dexetimide hydrochloride, isopropamide, atropine sulfate, nicotine, dl-amphetamine, sulfate, caffeine, desipramine hydrochloride, imipramine hydrochloride, cocaine, mescaline and LSD] with intrinsic stimulatory properties were not generalized with fentanyl treatment in rats trained to discriminate fentanyl (0.04 mg/kg, s.c., t-30'' [30 min]) from its solvent (s.c., t-30''). Five typical narcotic analgesics [morphine, dextromoramide tartrate, fentanyl, fentatienil and piritramide] yielded dose-dependent generalization with fentanyl treatment. The specific character of the narcotic cue in rats is supported.