Ultrastructural analysis of glycosaminoglycan hydrolysis in the rat periodontal ligament
- 1 December 1977
- journal article
- research article
- Published by Springer Nature in Calcified Tissue International
- Vol. 24 (1), 135-141
- https://doi.org/10.1007/bf02223307
Abstract
We identified the cellular sites of glycosaminoglycan hydrolysis by localizing a key enzyme, N-acetyl-β-glucosaminidase, in the rat periodonatal ligament. Reaction product was seen in osteoclasts, osteoblasts, fibroblasts, and in macrophages situated perivascularly in areas of bone remodelling. The preferential location of macrophages in areas of both bone formation and bone resorption, and their intense NAGase activity identified the macrophage as a significant participant in the total process of bone remodelling. We considered the presence of reaction product in the Golgi zone and the rough endoplasmic reticulum of osteoblasts and fibroblasts as possible localization of a NAG-transferase.This publication has 42 references indexed in Scilit:
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