The development of the human type II pneumocyte
- 1 April 1975
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 115 (4), 245-251
- https://doi.org/10.1002/path.1711150410
Abstract
Portions of lung from 25 human foetuses between 12 and 26 wk of gestational age were examined for ultrastructural changes during maturation of the epithelial cells. In 10 cases type I pneumocytes and in five cases type II cells were differentiated. The changes associated with the formation of lamellar inclusion bodies in type II cells are described. It is concluded that this is a synthetic process in which protein and lipid assembly are important. Changes in glycogen and participation of dense bodies are striking.Keywords
This publication has 11 references indexed in Scilit:
- Uptake of inert particulate matter by alveolar cells: An ultrastructural studyThe Journal of Pathology, 1973
- Autoradiographical and morphological evidence for apocrine secretion of dipalmitoyl lecithin in the terminal bronchiole of mouse lungJournal of Anatomy, 1973
- Lung Surfactant: Its Contribution to Lung DistensibilityProceedings of the Royal Society of Medicine, 1973
- Biochemical Development of Surface Activity in Mammalian Lung. IV. Pulmonary Lecithin Synthesis in the Human Fetus and Newborn and Etiology of the Respiratory Distress SyndromePediatric Research, 1972
- Electron microscopic observations on the morphogenesis of the albino rat lung, with special reference to pulmonary epithelial cellsJournal of Anatomy, 1970
- Inclusion bodies of type II alveolar cells: Species differences and morphogenesisThe Anatomical Record, 1969
- Bronchiolar and Large Alveolar Cell in Pulmonary Phospholipid MetabolismScience, 1967
- The Biochemical Development of Surface Activity in Mammalian Lung: II. The Biosynthesis of Phospholipids in the Lung of the Developing Rabbit Fetus and NewbornPediatric Research, 1967
- The Biochemical Development of Surface Activity in Mammalian Lung: I. The Surface-Active Phospholipids; the Separation and Distribution of Surface-Active Lecithin in the Lung of the Developing Rabbit FetusPediatric Research, 1967
- THE PULMONARY ALVEOLAR MUCOID FILM AND THE PNEUMONOCYTESThe Lancet, 1954